Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia

Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia

Abstract This study investigates whether serum D‐2HG (D‐2‐hydroxyglutarate) produced by the mutated isocitrate dehydrogenase (IDH) can predict IDH mutations in acute myeloid leukemia (AML) at diagnosis. D‐2HG and L‐2HG are measured by liquid chromatography‐tandem mass spectrometry. D‐2HG, total 2HG...

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Bibliographic Details
Main Authors: Chelsea Zhang, Andrew Chu, Richard Boriack, Robert Collins, Jing Xu, Dwight Oliver, Ruifang Zheng, Dinesh Rakheja, Weina Chen
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:eJHaem
Subjects:
acute myeloid leukemia
D‐2HG/L‐2HG Ratio
D‐2‐Hydroxyglutarate
IDH
L‐2‐Hydroxyglutarate
Online Access:https://doi.org/10.1002/jha2.723

Internet

https://doi.org/10.1002/jha2.723

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