Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia
Abstract This study investigates whether serum D‐2HG (D‐2‐hydroxyglutarate) produced by the mutated isocitrate dehydrogenase (IDH) can predict IDH mutations in acute myeloid leukemia (AML) at diagnosis. D‐2HG and L‐2HG are measured by liquid chromatography‐tandem mass spectrometry. D‐2HG, total 2HG...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-08-01
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| Series: | eJHaem |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jha2.723 |
| _version_ | 1797685621980921856 |
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| author | Chelsea Zhang Andrew Chu Richard Boriack Robert Collins Jing Xu Dwight Oliver Ruifang Zheng Dinesh Rakheja Weina Chen |
| author_facet | Chelsea Zhang Andrew Chu Richard Boriack Robert Collins Jing Xu Dwight Oliver Ruifang Zheng Dinesh Rakheja Weina Chen |
| author_sort | Chelsea Zhang |
| collection | DOAJ |
| description | Abstract This study investigates whether serum D‐2HG (D‐2‐hydroxyglutarate) produced by the mutated isocitrate dehydrogenase (IDH) can predict IDH mutations in acute myeloid leukemia (AML) at diagnosis. D‐2HG and L‐2HG are measured by liquid chromatography‐tandem mass spectrometry. D‐2HG, total 2HG and the D/L ratio (D‐2HG/L‐2HG) are significantly higher in IDHmutated cases than in IDHwild cases. The optimal cutoff values to predict IDH mutations at 100% sensitivity (specificity 91%–94%) are >588 ng/mL for D‐2HG and >2.33 for the D/L ratio. Our study indicates that elevated serum D‐2HG and the D/L ratio may serve as noninvasive biomarkers of IDH mutation in AML. |
| first_indexed | 2024-03-12T00:46:54Z |
| format | Article |
| id | doaj.art-4016bab4731d458cb950d8116b053e66 |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-03-12T00:46:54Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-4016bab4731d458cb950d8116b053e662023-09-14T15:30:47ZengWileyeJHaem2688-61462023-08-014372372710.1002/jha2.723Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemiaChelsea Zhang0Andrew Chu1Richard Boriack2Robert Collins3Jing Xu4Dwight Oliver5Ruifang Zheng6Dinesh Rakheja7Weina Chen8Departments of Pathology University of Texas Southwestern Medical Center Dallas Texas USADepartments of Pathology University of Texas Southwestern Medical Center Dallas Texas USAChildren's Medical Center Dallas Dallas Texas USAInternal Medicine (Hematology and Oncology) University of Texas Southwestern Medical Center Dallas Texas USADepartments of Pathology University of Texas Southwestern Medical Center Dallas Texas USADepartments of Pathology University of Texas Southwestern Medical Center Dallas Texas USADepartments of Pathology University of Texas Southwestern Medical Center Dallas Texas USADepartments of Pathology University of Texas Southwestern Medical Center Dallas Texas USADepartments of Pathology University of Texas Southwestern Medical Center Dallas Texas USAAbstract This study investigates whether serum D‐2HG (D‐2‐hydroxyglutarate) produced by the mutated isocitrate dehydrogenase (IDH) can predict IDH mutations in acute myeloid leukemia (AML) at diagnosis. D‐2HG and L‐2HG are measured by liquid chromatography‐tandem mass spectrometry. D‐2HG, total 2HG and the D/L ratio (D‐2HG/L‐2HG) are significantly higher in IDHmutated cases than in IDHwild cases. The optimal cutoff values to predict IDH mutations at 100% sensitivity (specificity 91%–94%) are >588 ng/mL for D‐2HG and >2.33 for the D/L ratio. Our study indicates that elevated serum D‐2HG and the D/L ratio may serve as noninvasive biomarkers of IDH mutation in AML.https://doi.org/10.1002/jha2.723acute myeloid leukemiaD‐2HG/L‐2HG RatioD‐2‐HydroxyglutarateIDHL‐2‐Hydroxyglutarate |
| spellingShingle | Chelsea Zhang Andrew Chu Richard Boriack Robert Collins Jing Xu Dwight Oliver Ruifang Zheng Dinesh Rakheja Weina Chen Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia eJHaem acute myeloid leukemia D‐2HG/L‐2HG Ratio D‐2‐Hydroxyglutarate IDH L‐2‐Hydroxyglutarate |
| title | Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia |
| title_full | Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia |
| title_fullStr | Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia |
| title_full_unstemmed | Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia |
| title_short | Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia |
| title_sort | serum d 2 hydroxyglutarate and the ratio of d 2hg l 2hg predict idh mutation in acute myeloid leukemia |
| topic | acute myeloid leukemia D‐2HG/L‐2HG Ratio D‐2‐Hydroxyglutarate IDH L‐2‐Hydroxyglutarate |
| url | https://doi.org/10.1002/jha2.723 |
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