Investigation of the Interaction of Human Origin Recognition Complex Subunit 1 with G-Quadruplex DNAs of Human <i>c-myc</i> Promoter and Telomere Regions

Investigation of the Interaction of Human Origin Recognition Complex Subunit 1 with G-Quadruplex DNAs of Human <i>c-myc</i> Promoter and Telomere Regions

Origin recognition complex (ORC) binds to replication origins in eukaryotic DNAs and plays an important role in replication. Although yeast ORC is known to sequence-specifically bind to a replication origin, how human ORC recognizes a replication origin remains unknown. Previous genome-wide studies...

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Bibliographic Details
Main Authors: Afaf Eladl, Yudai Yamaoki, Shoko Hoshina, Haruka Horinouchi, Keiko Kondo, Shou Waga, Takashi Nagata, Masato Katahira
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
origin recognition complex
G-quadruplex
DNA replication
replication origin
NMR
structure
Online Access:https://www.mdpi.com/1422-0067/22/7/3481

Internet

https://www.mdpi.com/1422-0067/22/7/3481

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