Prediction of Low-Dose Aspirin-Induced Gastric Toxicity Using Nuclear Magnetic Resonance Spectroscopy-Based Pharmacometabolomics in Rats

Prediction of Low-Dose Aspirin-Induced Gastric Toxicity Using Nuclear Magnetic Resonance Spectroscopy-Based Pharmacometabolomics in Rats

Background: Low-dose aspirin (LDA) is the backbone for secondary prevention of coronary artery disease, although limited by gastric toxicity. This study aimed to identify novel metabolites that could predict LDA-induced gastric toxicity using pharmacometabolomics. Methods: Pre-dosed urine samples we...

Full description

Bibliographic Details
Main Authors: Abubakar Sha’aban, Hadzliana Zainal, Nor Azlina Khalil, Fatimatuzzahra’ Abd Aziz, Ewe Seng Ch’ng, Chin-Hoe Teh, Mustapha Mohammed, Baharudin Ibrahim
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
aspirin
pharmacometabolomic
nuclear magnetic resonance
spectroscopy
gastric toxicity
multivariate analysis
Online Access:https://www.mdpi.com/1420-3049/27/7/2126

Internet

https://www.mdpi.com/1420-3049/27/7/2126

Similar Items