β-hydroxybutyrate impairs monocyte function via the ROS-NLR family pyrin domain-containing three inflammasome (NLRP3) pathway in ketotic cows

β-hydroxybutyrate impairs monocyte function via the ROS-NLR family pyrin domain-containing three inflammasome (NLRP3) pathway in ketotic cows

Cows with ketosis display severe metabolic stress and immune dysfunction which renders them more susceptible to infections. Monocytes, one of the major subtypes of white blood cells, play an important role in innate immune defense against infections. Thus, the aim of this study was to investigate al...

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Bibliographic Details
Main Authors: Zhihao Dong, Xudong Sun, Yan Tang, Shengbin Luo, Hongdou Jia, Qiushi Xu, Qianming Jiang, Juan J. Loor, Wei Xu, Chuang Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Veterinary Science
Subjects:
ketosis
monocytes
β-hydroxybutyric acid
oxidative stress
phagocytosis
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2022.925900/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2022.925900/full

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