High Mobility Group Box 1 Promotes Aortic Calcification in Chronic Kidney Disease via the Wnt/β-Catenin Pathway

High Mobility Group Box 1 Promotes Aortic Calcification in Chronic Kidney Disease via the Wnt/β-Catenin Pathway

Vascular calcification (VC) is common in chronic kidney disease (CKD), where cardiovascular mortality remains the leading cause of death. Here, we examined the role of high-mobility group box1 (HMGB1), a nuclear DNA-binding protein involved in inflammation, in aortic calcification and renal dysfunct...

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Bibliographic Details
Main Authors: Xiucai Jin, Shu Rong, Weijie Yuan, Lijie Gu, Jieshuang Jia, Ling Wang, Honglei Yu, Yifeng Zhuge
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Physiology
Subjects:
vascular calcification
chronic kidney disease
high-mobility group box1
β-catenin
renal dysfunction
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00665/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.00665/full

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