The endogenous HBZ interactome in ATL leukemic cells reveals an unprecedented complexity of host interacting partners involved in RNA splicing

The endogenous HBZ interactome in ATL leukemic cells reveals an unprecedented complexity of host interacting partners involved in RNA splicing

Adult T-cell leukemia/lymphoma (ATL) is a T-cell lymphoproliferative neoplasm caused by the human T-cell leukemia virus type 1 (HTLV-1). Two viral proteins, Tax-1 and HBZ play important roles in HTLV-1 infectivity and in HTLV-1-associated pathologies by altering key pathways of cell homeostasis. How...

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Bibliographic Details
Main Authors: Mariam Shallak, Tiziana Alberio, Mauro Fasano, Maria Monti, Ilaria Iacobucci, Julien Ladet, Franck Mortreux, Roberto S. Accolla, Greta Forlani
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
HTLV-1
HBZ
ATL
interactome
alternative splicing
protein network
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.939863/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.939863/full

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