Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance

Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance

Abstract Background Laminin-α5, a major component of the basal lamina, is predominantly synthesized by endothelial and mural cells (pericytes and vascular smooth muscle cells) in the CNS. Loss of laminin-α5 in either population fails to induce any abnormalities due to functional redundancy. Thus, th...

Full description

Bibliographic Details
Main Authors: Abhijit Nirwane, Minkyung Kang, Aravinthan Adithan, Vrishni Maharaj, Felicia Nguyen, Elliot Santaella Aguilar, Ava Nasrollahi, Yao Yao
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Fluids and Barriers of the CNS
Subjects:
Neurovascular unit
Transcytosis
Endothelial cells
Mural cells
Laminin-α5
Online Access:https://doi.org/10.1186/s12987-024-00521-z

Internet

https://doi.org/10.1186/s12987-024-00521-z

Similar Items