Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting

Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting

ABSTRACT In the apicomplexans, endocytosed cargos (e.g., hemoglobin) are trafficked to a specialized organelle for digestion. This follows a unique endocytotic process at the micropore/cytostome in these parasites. However, the mechanism underlying endocytic trafficking remains elusive, due to the r...

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Bibliographic Details
Main Authors: Qiang-Qiang Wang, Ming Sun, Tao Tang, De-Hua Lai, Jing Liu, Sanjay Maity, Kai He, Xi-Ting Wu, Jiong Yang, Yue-Bao Li, Xiao-Yan Tang, Hui-Yong Ding, Geoff Hide, Mark Distefano, Zhao-Rong Lun, Xing-Quan Zhu, Shaojun Long
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
apicomplexans
Toxoplasma gondii
malaria parasites
protein prenylation
prenylome
endocytic trafficking
Online Access:https://journals.asm.org/doi/10.1128/mbio.01309-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01309-23

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