Amyloid fibril formation kinetics of low-pH denatured bovine PI3K-SH3 monitored by three different NMR techniques

Amyloid fibril formation kinetics of low-pH denatured bovine PI3K-SH3 monitored by three different NMR techniques

Introduction: Misfolding of amyloidogenic proteins is a molecular hallmark of neurodegenerative diseases in humans. A detailed understanding of the underlying molecular mechanisms is mandatory for developing innovative therapeutic approaches. The bovine PI3K-SH3 domain has been a model system for ag...

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Bibliographic Details
Main Authors: Luis Gardon, Nina Becker, Nick Rähse, Christoph Hölbling, Athina Apostolidis, Celina M. Schulz, Kevin Bochinsky, Lothar Gremer, Henrike Heise, Nils-Alexander Lakomek
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
amyloid fibrils
fibrillation
aggregation kinetics
NMR spectroscopy
PI3K-SH3
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1254721/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2023.1254721/full

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