Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice

Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice

Abstract Background Frontotemporal dementia (FTD) is a heterogeneous group of early onset and progressive neurodegenerative disorders, characterized by degeneration in the frontal and temporal lobes, which causes deterioration in cognition, personality, social behavior and language. Around 45% of th...

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Bibliographic Details
Main Authors: Irene Santos-García, Carmen Rodríguez-Cueto, Patricia Villegas, Fabiana Piscitelli, Anna Lauritano, Che-Kun J. Shen, Vincenzo Di Marzo, Javier Fernández-Ruiz, Eva de Lago
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Neuroinflammation
Subjects:
Frontotemporal dementia
TDP-43
Cannabinoids
Endocannabinoid system
FAAH enzyme
URB597
Online Access:https://doi.org/10.1186/s12974-023-02792-z

Internet

https://doi.org/10.1186/s12974-023-02792-z

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