Amorphous Solid Dispersion of Hesperidin with Polymer Excipients for Enhanced Apparent Solubility as a More Effective Approach to the Treatment of Civilization Diseases

Amorphous Solid Dispersion of Hesperidin with Polymer Excipients for Enhanced Apparent Solubility as a More Effective Approach to the Treatment of Civilization Diseases

The present study reports amorphous solid dispersions (ASDs) of hesperidin (Hes) prepared by ball milling to improve its solubility and apparent solubility over the unmodified compound. The carriers were Soluplus<sup>®</sup> (Sol), alginate sodium (SA), and hydroxypropylmethylcellulose (...

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Bibliographic Details
Main Authors: Natalia Rosiak, Kamil Wdowiak, Ewa Tykarska, Judyta Cielecka-Piontek
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
hesperidin
amorphous solid dispersion
apparent solubility
glass transition
Gordon–Taylor equation
DFT calculation
Online Access:https://www.mdpi.com/1422-0067/23/23/15198

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https://www.mdpi.com/1422-0067/23/23/15198

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