Increase of Circulating Monocyte–Platelet Conjugates in Rheumatoid Arthritis Responders to IL-6 Blockage

Increase of Circulating Monocyte–Platelet Conjugates in Rheumatoid Arthritis Responders to IL-6 Blockage

Platelets (PLT) bind to a significant percentage of circulating monocytes and this immunomodulatory interaction is increased in several inflammatory and autoimmune conditions. The therapeutic blockage of IL-6 with Tocilizumab (TCZ) alters PLT and the phenotype and function of monocytes in rheumatoid...

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Bibliographic Details
Main Authors: Anaís Mariscal, Carlos Zamora, César Díaz-Torné, Mᵃ Àngels Ortiz, Juan José de Agustín, Delia Reina, Paula Estrada, Patricia Moya, Héctor Corominas, Sílvia Vidal
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
platelets
monocytes
rheumatoid arthritis
tocilizumab
immune modulation
inflammation
Online Access:https://www.mdpi.com/1422-0067/23/10/5748

Internet

https://www.mdpi.com/1422-0067/23/10/5748

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