Synthesis of Novel Acyl Derivatives of 3-(4,5,6,7-Tetrabromo-1<i>H</i>-benzimidazol-1-yl)propan-1-ols—Intracellular TBBi-Based CK2 Inhibitors with Proapoptotic Properties

Synthesis of Novel Acyl Derivatives of 3-(4,5,6,7-Tetrabromo-1<i>H</i>-benzimidazol-1-yl)propan-1-ols—Intracellular TBBi-Based CK2 Inhibitors with Proapoptotic Properties

Protein kinase CK2 has been considered as an attractive drug target for anti-cancer therapy. The synthesis of <i>N</i>-hydroxypropyl TBBi and 2MeTBBi derivatives as well as their respective esters was carried out by using chemoenzymatic methods. Concomitantly with kinetic studies toward...

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Bibliographic Details
Main Authors: Konrad Chojnacki, Patrycja Wińska, Olena Karatsai, Mirosława Koronkiewicz, Małgorzata Milner-Krawczyk, Monika Wielechowska, Maria Jolanta Rędowicz, Maria Bretner, Paweł Borowiecki
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
protein kinase CK2
CK2 inhibitors
breast cancer
tetrabromobenzimidazole
apoptosis
prodrug strategy
Online Access:https://www.mdpi.com/1422-0067/22/12/6261

Internet

https://www.mdpi.com/1422-0067/22/12/6261

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