PDLIM2 is highly expressed in Breast Cancer tumour-associated macrophages and is required for M2 macrophage polarization

PDLIM2 is highly expressed in Breast Cancer tumour-associated macrophages and is required for M2 macrophage polarization

The PDZ-LIM domain-containing protein 2 (PDLIM2) regulates cell polarity and the protein stability of key transcription factors in epithelial and hemopoietic cells. We previously reported that PDLIM2 is more highly expressed in Triple Negative Breast Cancer (TNBC) than in other breast cancer types o...

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Bibliographic Details
Main Authors: Orla T. Cox, Neil O’Sullivan, Emilie Tresse, Stephanie Ward, Niamh Buckley, Rosemary O’Connor
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
Triple Negative Breast Cancer (TNBC)
PDLIM2
M2 macrophage
cell differentiation
immune infiltration
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1028959/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1028959/full

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