New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses

New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses

Background: PRR (Pattern Recognition Receptor) agonists have been widely tested as potent vaccine adjuvants. TLR7 (Toll-Like Receptor 7) and NOD2 (nucleotide-binding oligomerization domain 2) are key innate receptors widely expressed at mucosal levels. Methods: Here, we evaluated the immunostimulato...

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Bibliographic Details
Main Authors: Alice Gutjahr, Laura Papagno, Fabienne Vernejoul, Thierry Lioux, Fabienne Jospin, Blandine Chanut, Eric Perouzel, Nicolas Rochereau, Victor Appay, Bernard Verrier, Stéphane Paul
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:EBioMedicine
Subjects:
Adjuvants
TLR7
NOD2
Vaccine
Chimeric
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420302978

Internet

http://www.sciencedirect.com/science/article/pii/S2352396420302978

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