Distribution of HLA-B Alleles and Haplotypes in Qatari: Recommendation for Establishing Pharmacogenomic Markers Screening for Drug Hypersensitivity

Distribution of HLA-B Alleles and Haplotypes in Qatari: Recommendation for Establishing Pharmacogenomic Markers Screening for Drug Hypersensitivity

Human leukocyte antigen (HLA) proteins are present at the cellular surface of antigen-presenting cells and play a crucial role in the adaptive immune response. Class I genes, specifically certain HLA-B alleles, are associated with adverse drug reactions (ADRs) and are used as pharmacogenetic markers...

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Bibliographic Details
Main Authors: Mohammed Dashti, Abdullah Al-Matrouk, Arshad Channanath, Prashantha Hebbar, Fahd Al-Mulla, Thangavel Alphonse Thanaraj
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
HLA-B alleles
pharmacogenetics
drug hypersensitivity
HLA typing class I
Qatari population
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.891838/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.891838/full

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