Reversible inhibitor of CRM1 sensitizes glioblastoma cells to radiation by blocking the NF-κB signaling pathway

Reversible inhibitor of CRM1 sensitizes glioblastoma cells to radiation by blocking the NF-κB signaling pathway

Abstract Background Activation of nuclear factor-kappa B (NF-κΒ) through DNA damage is one of the causes of tumor cell resistance to radiotherapy. Chromosome region 1 (CRM1) regulates tumor cell proliferation, drug resistance, and radiation resistance by regulating the nuclear-cytoplasmic translocat...

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Main Authors: Xuejiao Liu, Yiming Tu, Yifeng Wang, Di Zhou, Yulong Chong, Lin Shi, Guanzheng Liu, Xu Zhang, Sijin Wu, Huan Li, Shangfeng Gao, Mingshan Niu, Rutong Yu
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cancer Cell International
Subjects:
GBM
S109
CRM1
Irradiation
NF-κΒ signaling pathway
Online Access:http://link.springer.com/article/10.1186/s12935-020-01186-y

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http://link.springer.com/article/10.1186/s12935-020-01186-y

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