Neuroprotection by urokinase plasminogen activator in the hippocampus

Neuroprotection by urokinase plasminogen activator in the hippocampus

Tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which are both used for thrombolytic treatment of acute ischemic stroke, are serine proteases that convert plasminogen to active plasmin. Although recent experimental evidences have raised controversy about the neurotoxic...

Full description

Bibliographic Details
Main Authors: Eunsil Cho, Kyung Jin Lee, Jung-Woo Seo, Catherine Jeonghae Byun, Sun-Ju Chung, Dae Chul Suh, Peter Carmeliet, Jae-Young Koh, Jong S. Kim, Joo-Yong Lee
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Neurobiology of Disease
Subjects:
Plasminogen activators (PAs)
Epileptic seizures
Kainic acid
Excitotoxicity
Gliosis
Acute brain injury
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112000253

Internet

http://www.sciencedirect.com/science/article/pii/S0969996112000253

Similar Items