GSK-3: functional insights from cell biology and animal models

Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded in mammals by two genes that generate two related proteins: GSK-3α and GSK-3β. GSK-3 is active in cells under resting conditions and is primarily regulated through inhibition or dive...

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Bibliographic Details
Main Authors: Oksana eKaidanovich-Beilin, Jim Robert Woodgett
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2011.00040/full