Population Pharmacokinetics and Significant Under-Dosing of Anti-Tuberculosis Medications in People with HIV and Critical Illness

Population Pharmacokinetics and Significant Under-Dosing of Anti-Tuberculosis Medications in People with HIV and Critical Illness

Critical illness from tuberculosis (TB) bloodstream infection results in a high case fatality rate for people living with human immunodeficiency virus (HIV). Critical illness can lead to altered pharmacokinetics and suboptimal drug exposures. We enrolled adults living with HIV and hospitalized with...

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Bibliographic Details
Main Authors: Prakruti S. Rao, Christopher C. Moore, Amir A. Mbonde, Edwin Nuwagira, Patrick Orikiriza, Dan Nyehangane, Mohammad H. Al-Shaer, Charles A. Peloquin, Jean Gratz, Suporn Pholwat, Rinah Arinaitwe, Yap Boum, Juliet Mwanga-Amumpaire, Eric R. Houpt, Leonid Kagan, Scott K. Heysell, Conrad Muzoora
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antibiotics
Subjects:
TB bacteremia
sepsis
meningitis
HIV
pharmacokinetics
population modeling
Online Access:https://www.mdpi.com/2079-6382/10/6/739

Internet

https://www.mdpi.com/2079-6382/10/6/739

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