<i>Bcl2l1</i> Deficiency in Osteoblasts Reduces the Trabecular Bone Due to Enhanced Osteoclastogenesis Likely through Osteoblast Apoptosis

<i>Bcl2l1</i> Deficiency in Osteoblasts Reduces the Trabecular Bone Due to Enhanced Osteoclastogenesis Likely through Osteoblast Apoptosis

Bcl2l1 (Bcl-XL) belongs to the Bcl-2 family, Bcl2 and Bcl2-XL are major anti-apoptotic proteins, and the apoptosis of osteoblasts is a key event for bone homeostasis. As the functions of Bcl2l1 in osteoblasts and bone homeostasis remain unclear, we generated osteoblast-specific <i>Bcl2l1</i...

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Bibliographic Details
Main Authors: Takeshi Moriishi, Yosuke Kawai, Ryo Fukuyama, Yuki Matsuo, You-Wen He, Haruhiko Akiyama, Izumi Asahina, Toshihisa Komori
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
Bcl2l1
Bcl-XL
apoptosis
ATP
Tnfsf11
osteoblast
Online Access:https://www.mdpi.com/1422-0067/24/24/17319

Internet

https://www.mdpi.com/1422-0067/24/24/17319

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