IFN-γ transforms the transcriptomic landscape and triggers myeloid cell hyperresponsiveness to cause lethal lung injury

IFN-γ transforms the transcriptomic landscape and triggers myeloid cell hyperresponsiveness to cause lethal lung injury

Acute Respiratory Distress Syndrome (ARDS) is an inflammatory disease that is associated with high mortality but no specific treatment. Our understanding of initial events that trigger ARDS pathogenesis is limited. We have developed a mouse model of inflammatory lung injury by influenza and methicil...

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Bibliographic Details
Main Authors: Atul K. Verma, Michael McKelvey, Md Bashir Uddin, Sunil Palani, Meng Niu, Christopher Bauer, Shengjun Shao, Keer Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Acute lung injury
cytokine storm
influenza A virus
methicillin-resistant Staphylococcus aureus
coinfection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1011132/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1011132/full

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