Mechanism of action of paclitaxel for treating glioblastoma based on single-cell RNA sequencing data and network pharmacology

Mechanism of action of paclitaxel for treating glioblastoma based on single-cell RNA sequencing data and network pharmacology

Paclitaxel is an herbal active ingredient used in clinical practice that shows anti-tumor effects. However, its biological activity, mechanism, and cancer cell-killing effects remain unknown. Information on the chemical gene interactions of paclitaxel was obtained from the Comparative Toxicogenomics...

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Bibliographic Details
Main Authors: Jianglong Lu, Fanjie Xu, Changjun Rao, Chaodong Shen, Jinghao Jin, Zhangzhang Zhu, Chengde Wang, Qun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
glioblastoma
paclitaxel
single-cell RNA sequencing
bioinformatics
network pharmacology
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1076958/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1076958/full

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