Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function.

Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function.

Approximately half of hereditary breast cancers have mutations in either BRCA1 or BRCA2. BRCA1 is a multifaceted tumor suppressor protein that has implications in processes such as cell cycle, transcription, DNA damage response and chromatin remodeling. This multifunctional nature of BRCA1 is achiev...

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Bibliographic Details
Main Authors: Irene Guendel, Lawrence Carpio, Caitlin Pedati, Arnold Schwartz, Christine Teal, Fatah Kashanchi, Kylene Kehn-Hall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2894074?pdf=render

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http://europepmc.org/articles/PMC2894074?pdf=render

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