Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model

Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model

Summary: Tau pathobiology has emerged as a key component underlying Alzheimer's disease (AD) progression; however, human neuronal in vitro models have struggled to recapitulate tau phenomena observed in vivo. Here, we aimed to define the minimal requirements to achieve endogenous tau aggregatio...

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Bibliographic Details
Main Authors: Justine D. Manos, Christina N. Preiss, Nandini Venkat, Joseph Tamm, Peter Reinhardt, Taekyung Kwon, Jessica Wu, Allison D. Winter, Thomas R. Jahn, Kiran Yanamandra, Katherine Titterton, Eric Karran, Xavier Langlois
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:iScience
Subjects:
Molecular neuroscience
Cellular neuroscience
Stem cells research
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422101628X

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http://www.sciencedirect.com/science/article/pii/S258900422101628X

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