Proteomic Profiling of SGLT-2 Inhibitor Canagliflozin in a Swine Model of Chronic Myocardial Ischemia

Proteomic Profiling of SGLT-2 Inhibitor Canagliflozin in a Swine Model of Chronic Myocardial Ischemia

Background: Sodium–glucose cotransporter-2 (SGLT2) inhibitors are known to be cardioprotective independent of glucose control, but the mechanisms of these benefits are unclear. We previously demonstrated improved cardiac function and decreased fibrosis in a swine model of chronic myocardial ischemia...

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Bibliographic Details
Main Authors: Dwight D. Harris, Sharif A. Sabe, Mark Broadwin, Christopher Stone, Cynthia Xu, Jiayu Hu, Meghamsh Kanuparthy, M. Ruhul Abid, Frank W. Sellke
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Biomedicines
Subjects:
sodium–glucose cotransporter-2 inhibitors
proteomic
swine
chronic myocardial ischemia
canagliflozin
cardiac index
Online Access:https://www.mdpi.com/2227-9059/12/3/588

Internet

https://www.mdpi.com/2227-9059/12/3/588

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