Hirsutanol A Attenuates Lipopolysaccharide-Mediated Matrix Metalloproteinase 9 Expression and Cytokines Production and Improves Endotoxemia-Induced Acute Sickness Behavior and Acute Lung Injury

Hirsutanol A Attenuates Lipopolysaccharide-Mediated Matrix Metalloproteinase 9 Expression and Cytokines Production and Improves Endotoxemia-Induced Acute Sickness Behavior and Acute Lung Injury

Activated human monocytes/macrophages, which increase the levels of matrix metalloproteinases (MMPs) and pro-inflammatory cytokines, are the essential mechanisms for the progression of sepsis. In the present study, we determined the functions and mechanisms of hirsutanolA (HA), which is isolated fro...

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Bibliographic Details
Main Authors: Jing-Shiun Jan, Chih-Hao Yang, Mong-Heng Wang, Fan-Li Lin, Jing-Lun Yen, Irene Hsieh, Maksim Khotimchenko, Tzong-Huei Lee, George Hsiao
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Marine Drugs
Subjects:
signal transducer and activator of transcription 3 (STAT3)
matrix metalloproteinases-9 (MMP-9)
interleukin (IL)
lipopolysaccharide (LPS)
acute sickness behavior
acute lung injury (ALI)
Online Access:https://www.mdpi.com/1660-3397/17/6/360

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https://www.mdpi.com/1660-3397/17/6/360

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