Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity

Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity

Durable serological memory following vaccination is critically dependent on the production and survival of long-lived plasma cells (LLPCs). Yet, the factors that control LLPC specification and survival remain poorly resolved. Using intravital two-photon imaging, we find that in contrast to most plas...

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Bibliographic Details
Main Authors: Zhixin Jing, Phillip Galbo, Luis Ovando, Megan Demouth, Skylar Welte, Rosa Park, Kartik Chandran, Yinghao Wu, Thomas MacCarthy, Deyou Zheng, David Fooksman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-06-01
Series:eLife
Subjects:
CXCR4
vaccination
bone marrow
multiphoton
long-lived plasma cells
antibody
Online Access:https://elifesciences.org/articles/89712

Internet

https://elifesciences.org/articles/89712

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