GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment

GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment

Abstract Background The G protein estrogen receptor GPER/GPR30 mediates estrogen action in breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key components of microenvironment driving tumor progression. GPER is a transcriptional target of hypoxia inducible fact...

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Bibliographic Details
Main Authors: Ernestina M. De Francesco, Andrew H. Sims, Marcello Maggiolini, Federica Sotgia, Michael P. Lisanti, Robert B. Clarke
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Breast Cancer Research
Subjects:
GPER
VEGF
HIF-1α
CAFs
IGF1
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s13058-017-0923-5

Internet

http://link.springer.com/article/10.1186/s13058-017-0923-5

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