A variant NS1 protein from H5N2 avian influenza virus suppresses PKR activation and promotes replication and virulence in mammals

A variant NS1 protein from H5N2 avian influenza virus suppresses PKR activation and promotes replication and virulence in mammals

Highly pathogenic avian influenza viruses (HPAIVs) frequently receive global attention as threats to public health. The NS1 protein is a key virulence factor known to impair host antiviral responses. The study herein revealed HPAIV H5N2 NS gene encoded additional protein; a truncated NS1 variant, de...

Full description

Bibliographic Details
Main Authors: Yun-Ting Chung, Chih-Ying Kuan, Guan-Ru Liao, Randy A. Albrecht, Yeu-Yang Tseng, Yu-Chen Hsu, Shan-Chia Ou, Wei-Li Hsu
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Emerging Microbes and Infections
Subjects:
Highly pathogenic avian influenza viruses
NS1
NS3
cytokine
PKR
host range
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2022.2114853

Internet

https://www.tandfonline.com/doi/10.1080/22221751.2022.2114853

Similar Items