Knockout of IL-6 mitigates cold water-immersion restraint stress-induced intestinal epithelial injury and apoptosis

Knockout of IL-6 mitigates cold water-immersion restraint stress-induced intestinal epithelial injury and apoptosis

BackgroundInterleukin-6 (IL-6) is essential for maintaining intestinal epithelial homeostasis. Although cold water-immersion restraint (CWIR) stress is commonly used to induce in vivo gastric injury, it also affects intestinal epithelial permeability. Although IL-6 is increased in response to acute...

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Bibliographic Details
Main Authors: Yuan Zhang, Chujun Duan, Shuwen Wu, Jingchang Ma, Yongming Liu, Wenpeng Li, Tingting Wang, Lu Yang, Kun Cheng, Ran Zhuang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
IL-6
distress
intestinal mucosal barrier
KO mice
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.936689/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.936689/full

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