The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing.

The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing.

Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address this challenge, our group has developed a computational model, rooted in physics, that aims to predict the fitness landscape of HIV-1 proteins in order to design vaccine immunogens that lead to impair...

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Bibliographic Details
Main Authors: Jaclyn K Mann, John P Barton, Andrew L Ferguson, Saleha Omarjee, Bruce D Walker, Arup Chakraborty, Thumbi Ndung'u
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-08-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4125067?pdf=render

Internet

http://europepmc.org/articles/PMC4125067?pdf=render

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