4-Octyl itaconate treatment inhibits mitochondrial dysfunction and ER stress via stimulating SIRT1 expression in vitro and attenuates osteoarthritis process in murine DMM model in vivo

4-Octyl itaconate treatment inhibits mitochondrial dysfunction and ER stress via stimulating SIRT1 expression in vitro and attenuates osteoarthritis process in murine DMM model in vivo

Osteoarthritis (OA), a degenerative disease, has many pathological factors, including oxidative stress (OS), endoplasmic reticulum (ER) stress, apoptosis, and extracellular matrix (ECM) degeneration. OS regulates the pathological progression of OA via mitochondrial dysfunction, and ER stress and by...

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Bibliographic Details
Main Authors: Ziping Yu, Zhao Zhang, Xuancheng Zhang, Junduo Bao, Hualin Li, Jiapei Yu, Ning Shi, Fulong Nan, Liang Cao, Chenghui Li, Wei Wang
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Journal of Functional Foods
Subjects:
Reactive oxygen species
Osteoarthritis
Endoplasmic reticulum
Mitochondrial dysfunction
4-Octyl itaconate
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464623000506

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http://www.sciencedirect.com/science/article/pii/S1756464623000506

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