DNMT3B overexpression downregulates genes with CpG islands, common motifs, and transcription factor binding sites that interact with DNMT3B

DNMT3B overexpression downregulates genes with CpG islands, common motifs, and transcription factor binding sites that interact with DNMT3B

Abstract DNA methylation is a key epigenetic modification to regulate gene expression in mammalian cells. Abnormal DNA methylation in gene promoters is common across human cancer types. DNMT3B is the main de novo methyltransferase enhanced in several primary tumors. How de novo methylation is establ...

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Bibliographic Details
Main Authors: Jaqueline Loaeza-Loaeza, Angel Josué Cerecedo-Castillo, Hugo Alberto Rodríguez-Ruiz, Yaneth Castro-Coronel, Oscar Del Moral-Hernández, Félix Recillas-Targa, Daniel Hernández-Sotelo
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-24186-6

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https://doi.org/10.1038/s41598-022-24186-6

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