Inhibition of Histone Deacetylases Induces K+ Channel Remodeling and Action Potential Prolongation in HL-1 Atrial Cardiomyocytes

Inhibition of Histone Deacetylases Induces K+ Channel Remodeling and Action Potential Prolongation in HL-1 Atrial Cardiomyocytes

Background/Aims: Cardiac arrhythmias are triggered by environmental stimuli that may modulate expression of cardiac ion channels. Underlying epigenetic regulation of cardiac electrophysiology remains incompletely understood. Histone deacetylases (HDACs) control gene expression and cardiac integrity....

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Bibliographic Details
Main Authors: Patrick Lugenbiel, Katharina Govorov, Ann-Kathrin Rahm, Teresa Wieder, Dominik Gramlich, Pascal Syren, Nadine Weiberg, Claudia Seyler, Hugo A. Katus, Dierk Thomas
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Atrial fibrillation
Cardiac action potential
Epigenetic regulation
Histone deacetylase
Ion channel
Potassium channel
Tachypacing
Trichostatin A
Online Access:https://www.karger.com/Article/FullText/492840

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https://www.karger.com/Article/FullText/492840

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