Mechanical stimulation promotes MSCs healing the lesion of intervertebral disc annulus fibrosus

Mechanical stimulation promotes MSCs healing the lesion of intervertebral disc annulus fibrosus

Mesenchymal stem cells (MSCs) and scaffolds offer promising perspectives for annulus fibrosus (AF) repair. The repair effect was linked to features of the local mechanical environment related to the differentiation of MSCs. In this study, we established a Fibrinogen-Thrombin-Genipin (Fib-T-G) gel wh...

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Bibliographic Details
Main Authors: Rongrong Deng, Ran Kang, Xiaoyu Jin, Zihan Wang, Xin Liu, Qing Wang, Lin Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
mesenchymal stem cells
gel scaffold
intervertebral disc annulus fibrosus
mechanical stimulation
RhoA/Rock1 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1137199/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1137199/full

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