Genkwanin suppresses mitochondrial dysfunction to alleviate IL-1β-elicited inflammation, apoptosis, and degradation of extracellular matrix in chondrocytes through upregulating DUSP1

Genkwanin suppresses mitochondrial dysfunction to alleviate IL-1β-elicited inflammation, apoptosis, and degradation of extracellular matrix in chondrocytes through upregulating DUSP1

Osteoarthritis (OA) is a form of chronic degenerative disease contributing to elevated disability rate among the elderly. Genkwanin is an active component extracted from Daphne genkwa possessing pharmacologic effects. Here, this study is designed to expound the specific role of genkwanin in OA and e...

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Bibliographic Details
Main Authors: Kanna Xu, Haoran Wang, Zhongqing Wu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Chinese Journal of Physiology
Subjects:
dual-specificity protein phosphatase-1
extracellular matrix degradation
genkwanin
inflammatory response
osteoarthritis
Online Access:http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2023;volume=66;issue=4;spage=284;epage=293;aulast=Xu

Internet

http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2023;volume=66;issue=4;spage=284;epage=293;aulast=Xu

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