PBK/TOPK inhibitor OTS964 resistance is mediated by ABCB1-dependent transport function in cancer: in vitro and in vivo study

PBK/TOPK inhibitor OTS964 resistance is mediated by ABCB1-dependent transport function in cancer: in vitro and in vivo study

Highlights ABCB1 overexpression significantly desensitized both drug-selected and gene-transfected cells, which overexpress ABCB1, to OTS964 and that this drug resistance can be antagonized by verapamil, a known ABCB1 inhibitor. Consistently, a similar trend was observed in tumor-bearing mice. OTS96...

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Bibliographic Details
Main Authors: Yuqi Yang, Qiu-Xu Teng, Zhuo-Xun Wu, Jing-Quan Wang, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Ning Ji, Zhe-Sheng Chen
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Molecular Cancer
Subjects:
T-LAK cell-originated protein kinase (TOPK)
PDZ-binding kinase (PBK)
OTS964
ATP-binding cassette sub-family B member 1 (ABCB1)
Multidrug resistance (MDR)
Online Access:https://doi.org/10.1186/s12943-022-01512-0

Internet

https://doi.org/10.1186/s12943-022-01512-0

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