Inhibition of the ATP Synthase Eliminates the Intrinsic Resistance of <italic toggle="yes">Staphylococcus aureus</italic> towards Polymyxins

Inhibition of the ATP Synthase Eliminates the Intrinsic Resistance of <italic toggle="yes">Staphylococcus aureus</italic> towards Polymyxins

ABSTRACT Staphylococcus aureus is intrinsically resistant to polymyxins (polymyxin B and colistin), an important class of cationic antimicrobial peptides used in treatment of Gram-negative bacterial infections. To understand the mechanisms underlying intrinsic polymyxin resistance in S. aureus, we s...

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Bibliographic Details
Main Authors: Martin Vestergaard, Katrine Nøhr-Meldgaard, Martin Saxtorph Bojer, Christina Krogsgård Nielsen, Rikke Louise Meyer, Christoph Slavetinsky, Andreas Peschel, Hanne Ingmer
Format: Article
Language:English
Published: American Society for Microbiology 2017-11-01
Series:mBio
Subjects:
ATP synthase
Staphylococcus aureus
antimicrobial peptides
atpA
intrinsic resistance
oligomycin A
Online Access:https://journals.asm.org/doi/10.1128/mBio.01114-17

Internet

https://journals.asm.org/doi/10.1128/mBio.01114-17

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