Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

Translational control depends on phosphorylation of eIF2α by PKR-like ER kinase (PERK). To examine the role of PERK in cognitive function, we selectively disrupted PERK expression in the adult mouse forebrain. In the prefrontal cortex (PFC) of PERK-deficient mice, eIF2α phosphorylation and ATF4 expr...

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Bibliographic Details
Main Authors: Mimi A. Trinh, Hanoch Kaphzan, Ronald C. Wek, Philippe Pierre, Douglas R. Cavener, Eric Klann
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712001234

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http://www.sciencedirect.com/science/article/pii/S2211124712001234

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