Improving cancer immunotherapy by rationally combining oncolytic virus with modulators targeting key signaling pathways

Abstract Oncolytic viruses (OVs) represent a new class of multi-modal immunotherapies for cancer, with OV-elicited antitumor immunity being key to their overall therapeutic efficacy. Currently, the clinical effectiveness of OV as monotherapy remains limited, and thus investigators have been explorin...

Full description

Bibliographic Details
Main Authors: Zhi Zhu, A. J. Robert McGray, Weijian Jiang, Binfeng Lu, Pawel Kalinski, Zong Sheng Guo
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Molecular Cancer
Subjects:
Online Access:https://doi.org/10.1186/s12943-022-01664-z