Identification of novel KRASG12D neoantigen specific TCRs and a strategy to eliminate off-target recognition

Identification of novel KRASG12D neoantigen specific TCRs and a strategy to eliminate off-target recognition

Abstract Background T cell receptor (TCR)–engineered T cells targeting neoantigens originated from mutations in KRAS gene have demonstrated promising outcomes in clinical trials against solid tumors. However, the challenge lies in developing tumor-specific TCRs that avoid cross-reactivity with self-...

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Bibliographic Details
Main Authors: Xiaojian Han, Xiaxia Han, Yanan Hao, Bozhi Wang, Luo Li, Siyin Chen, Lin Zou, Jingjing Huang, Tong Chen, Wang Wang, Shengchun Liu, Aishun Jin, Meiying Shen
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
KRAS mutation
T cell receptor
Cross-reactivity
Off-target
Online Access:https://doi.org/10.1186/s12967-025-06094-1

Internet

https://doi.org/10.1186/s12967-025-06094-1

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