Upregulation of carbonic anhydrase 1 beneficial for depressive disorder

Upregulation of carbonic anhydrase 1 beneficial for depressive disorder

Abstract Carbonic Anhydrase 1 (CAR1) is a zinc-metalloenzyme that catalyzes the hydration of carbon dioxide, and the alteration of CAR1 has been implicated in neuropsychiatric disorders. However, the mechanism underlying the role of CAR1 in major depressive disorder (MDD) remains largely unknown. In...

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Bibliographic Details
Main Authors: Ke Cheng, Yue Wang, Yong He, Yu Tian, Junjie Li, Chong Chen, Xingzhe Xu, Zhonghao Wu, Heming Yu, Xiangyu Chen, Yili Wu, Weihong Song, Zhifang Dong, Huatai Xu, Peng Xie
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Acta Neuropathologica Communications
Subjects:
Carbonic anhydrase 1
Hippocampal astrocytes
Miniature inhibitory postsynaptic currents
CAR1-knockout mice
Major depressive disorder
Online Access:https://doi.org/10.1186/s40478-023-01545-6

Internet

https://doi.org/10.1186/s40478-023-01545-6

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