Plasma lipidomic profiling of thiopurine-induced leukopenia after NUDT15 genotype-guided dosing in Chinese IBD patients

Plasma lipidomic profiling of thiopurine-induced leukopenia after NUDT15 genotype-guided dosing in Chinese IBD patients

IntroductionThiopurines, azathiopurine (AZA) and mercaptopurine (6-MP) have been regularly used in the treatment of inflammatory bowel disease (IBD). Despite optimized dosage adjustment based on the NUDT15 genotypes, some patients still discontinue or change treatment regimens due to thiopurine-indu...

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Bibliographic Details
Main Authors: Pan Li, Kang Chao, Zhanhua Hu, Lulu Qin, Ting Yang, Jing Mao, Xia Zhu, Pinjin Hu, Xueding Wang, Xiang Gao, Min Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Nutrition
Subjects:
thiopurines
lipidomic
inflammatory bowel disease
biomarkers
machine learning
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2023.1138506/full

Internet

https://www.frontiersin.org/articles/10.3389/fnut.2023.1138506/full

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