Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets.

Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets.

Loss of pancreatic beta cells is a feature of type-2 diabetes. High glucose concentrations induce endoplasmic reticulum (ER) and oxidative stress-mediated apoptosis of islet cells in vitro. ER stress, oxidative stress and high glucose concentrations may also activate the NLRP3 inflammasome leading t...

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Détails bibliographiques
Auteurs principaux: Jibran A Wali, Esteban N Gurzov, Stacey Fynch, Lorraine Elkerbout, Thomas W Kay, Seth L Masters, Helen E Thomas
Format: Article
Langue:English
Publié: Public Library of Science (PLoS) 2014-01-01
Collection:PLoS ONE
Accès en ligne:http://europepmc.org/articles/PMC4236141?pdf=render

Internet

http://europepmc.org/articles/PMC4236141?pdf=render

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