The STAT3 inhibitor GPB730 enhances the sensitivity to enzalutamide in prostate cancer cells

Enzalutamide is a second-generation anti-androgen which has shown increased survival in patients with metastatic prostate cancer. However, some patients do not respond to this therapy or will develop resistance to treatment over time. Signal Transducer and Activator of Transcription 3 (STAT3) is kno...

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Bibliographic Details
Main Authors: Rebecka Hellsten, Anna Stiehm, Macarena Palominos, Margareta Persson, Anders Bjartell
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Translational Oncology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523322001541