Gardenin A treatment attenuates inflammatory markers, synuclein pathology and deficits in tyrosine hydroxylase expression and improves cognitive and motor function in A53T-α-syn mice

Gardenin A treatment attenuates inflammatory markers, synuclein pathology and deficits in tyrosine hydroxylase expression and improves cognitive and motor function in A53T-α-syn mice

Oxidative stress and neuroinflammation are widespread in the Parkinson’s disease (PD) brain and contribute to the synaptic degradation and dopaminergic cell loss that result in cognitive impairment and motor dysfunction. The polymethoxyflavone Gardenin A (GA) has been shown to activate the NRF2-regu...

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Bibliographic Details
Main Authors: Wyatt Hack, Noah Gladen-Kolarsky, Swarnali Chatterjee, Qiaoli Liang, Urmila Maitra, Lukasz Ciesla, Nora E. Gray
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Parkinson’s Disease
Alpha-synuclein
Cognition
Motor function
Gardenin A
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224002543

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http://www.sciencedirect.com/science/article/pii/S0753332224002543

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