Effect of Recombinant α1-Antitrypsin Fc-Fused (AAT-Fc) Protein on the Inhibition of Inflammatory Cytokine Production and Streptozotocin-Induced Diabetes

Effect of Recombinant α1-Antitrypsin Fc-Fused (AAT-Fc) Protein on the Inhibition of Inflammatory Cytokine Production and Streptozotocin-Induced Diabetes

Abstract α1-Antitrypsin (AAT) is a member of the serine proteinase inhibitor family that impedes the enzymatic activity of serine proteinases, including human neutrophil elastase, cathepsin G and neutrophil proteinase 3. Here, we expressed recombinant AAT by fusing the intact AAT gene to the constan...

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Bibliographic Details
Main Authors: Siyoung Lee, Youngmin Lee, Kwangwon Hong, Jaewoo Hong, Suyoung Bae, Jida Choi, Hyunjhung Jhun, Areum Kwak, Eunsom Kim, Seunghyun Jo, Charles A. Dinarello, Soohyun Kim
Format: Article
Language:English
Published: BMC 2013-03-01
Series:Molecular Medicine
Subjects:
Human PBMCs
Streptozotocin-induced Mouse Model
Serine Protease Inhibitor Family
Elastase Activity
Neutrophil Proteases
Online Access:https://doi.org/10.2119/molmed.2012.00308

Internet

https://doi.org/10.2119/molmed.2012.00308

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