Overexpression of transcriptional regulator and tailoring enzyme leads to the discovery of anti-inflammatory meroterpenoids from marine-derived fungus Alternaria alternata JJY-32

Overexpression of transcriptional regulator and tailoring enzyme leads to the discovery of anti-inflammatory meroterpenoids from marine-derived fungus Alternaria alternata JJY-32

Four new ACTG-toxins like meroterpenoids tricycloalternarenes O-R were discovered from a marine-derived fungus Alternaria alternata JJY-32 by the overexpression of a LaeA-like global transcriptional regulator and a MpaB-like biosynthetic tailoring enzyme. Among those structures, tricycloalternarene...

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Bibliographic Details
Main Authors: Guowei Liu, Dan Liu, Zongyuan Li, Jieying Jiao, Xuewen Hou, Xiaomin Zhang, Qian Che, Tianjiao Zhu, Dehai Li, Guojian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Marine Science
Subjects:
Alternaria alternata
meroterpenoid
transcriptional regulator
tailoring enzyme
anti-inflammatory
Online Access:https://www.frontiersin.org/articles/10.3389/fmars.2022.1015684/full

Internet

https://www.frontiersin.org/articles/10.3389/fmars.2022.1015684/full

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